Cargando…

Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications

As people age, iron deposits in different areas of the brain may impair normal cognitive function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the Fenton reaction, triggers oxidative stress reactions, damages cell lipids, protein and DNA structure and function, and ulti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jun-Lin, Fan, Yong-Gang, Yang, Zheng-Sheng, Wang, Zhan-You, Guo, Chuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139360/ https://www.ncbi.nlm.nih.gov/pubmed/30250423 http://dx.doi.org/10.3389/fnins.2018.00632

Ejemplares similares

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials
por: Miao, Jifei, et al.
Publicado: (2023)

Lower Expression of Ndfip1 Is Associated With Alzheimer Disease Pathogenesis Through Decreasing DMT1 Degradation and Increasing Iron Influx
por: Tian, Juan, et al.
Publicado: (2018)

Role of miR-211 in Neuronal Differentiation and Viability: Implications to Pathogenesis of Alzheimer’s Disease
por: Fan, Chunying, et al.
Publicado: (2016)

The Role of Iron-Induced Fibrin in the Pathogenesis of Alzheimer’s Disease and the Protective Role of Magnesium
por: Lipinski, Boguslaw, et al.
Publicado: (2013)

Glucocerebrosidase Mutations Cause Mitochondrial and Lysosomal Dysfunction in Parkinson’s Disease: Pathogenesis and Therapeutic Implications
por: Zheng, Wei, et al.
Publicado: (2022)

Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease
por: Lu, Xi, et al.
Publicado: (2015)

Inflamma-MicroRNAs in Alzheimer’s Disease: From Disease Pathogenesis to Therapeutic Potentials
por: Liang, Yuanyuan, et al.
Publicado: (2021)

Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease
por: Ekundayo, Temitope Cyrus, et al.
Publicado: (2021)

The emerging role of autophagy and mitophagy in tauopathies: From pathogenesis to translational implications in Alzheimer’s disease
por: Liu, Xiaolan, et al.
Publicado: (2022)

NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications
por: Leibowitz, Saskia M., et al.
Publicado: (2016)

Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease
por: Yan, Nao, et al.
Publicado: (2020)

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches
por: Morales, Inelia, et al.
Publicado: (2014)

Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies
por: Li, Dan-Dan, et al.
Publicado: (2017)

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications
por: Uddin, Md. Sahab, et al.
Publicado: (2018)

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
por: Wang, Xin, et al.
Publicado: (2017)

Clinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer’s disease
por: Mumtaz, Ibtisam, et al.
Publicado: (2022)

Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues
por: Liang, Junyi, et al.
Publicado: (2023)

Implications of GABAergic Neurotransmission in Alzheimer’s Disease
por: Li, Yanfang, et al.
Publicado: (2016)

The Role of Exosomes as Mediators of Neuroinflammation in the Pathogenesis and Treatment of Alzheimer’s Disease
por: Weng, Shiting, et al.
Publicado: (2022)

Hepcidin Increases Cytokines in Alzheimer’s Disease and Down’s Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation
por: Raha, Animesh Alexander, et al.
Publicado: (2021)

Investigation of brain iron levels in Chinese patients with Alzheimer’s disease
por: Huang, Chuanbin, et al.
Publicado: (2023)

Potential Implications of miRNAs in the Pathogenesis, Diagnosis, and Therapeutics of Alzheimer’s Disease
por: Wang, Long, et al.
Publicado: (2023)

Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues
por: He, Da-Long, et al.
Publicado: (2023)

Role of TGFβ signaling in the pathogenesis of Alzheimer’s disease
por: von Bernhardi, Rommy, et al.
Publicado: (2015)

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis
por: Chakravorty, Anushka, et al.
Publicado: (2019)

The Eminent Role of microRNAs in the Pathogenesis of Alzheimer's Disease
por: Samadian, Mohammad, et al.
Publicado: (2021)

Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease
por: Morgan, Sarah L., et al.
Publicado: (2022)

Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications
por: Wang, Jun, et al.
Publicado: (2014)

Editorial: Biomarkers and therapeutic targets in the pathogenesis of neurodegenerative diseases: Functions, implications, and perspectives
por: Wang, Junhui
Publicado: (2023)

Relationship between adult subventricular neurogenesis and Alzheimer’s disease: Pathologic roles and therapeutic implications
por: Kim, Hyeon Soo, et al.
Publicado: (2022)

Implications of Glycosylation in Alzheimer’s Disease
por: Haukedal, Henriette, et al.
Publicado: (2021)

Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease
por: Gao, Ge, et al.
Publicado: (2019)

The Fourth Element Targeting Hypothesis of Alzheimer's Disease Pathogenesis and Pathophysiology
por: Kuljiš, Rodrigo O.
Publicado: (2010)

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease
por: Chesser, Adrianne S., et al.
Publicado: (2013)

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease
por: Ohno, Masuo
Publicado: (2014)

Involvement of Astrocytes and microRNA Dysregulation in Neurodegenerative Diseases: From Pathogenesis to Therapeutic Potential
por: Bai, Yang, et al.
Publicado: (2021)

Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis
por: Dzamko, Nicolas, et al.
Publicado: (2014)

Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease
por: Wang, Yi, et al.
Publicado: (2022)

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
por: Tiwari, Sneham, et al.
Publicado: (2019)

Novel molecular mechanisms in Alzheimer’s disease: The potential role of DEK in disease pathogenesis
por: Greene, Allie N., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qs19h35fr14c74jd81li80ma66