Cargando…

The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity

Mainstay therapeutics are ineffective in some people with asthma, suggesting a need for additional agents. In the current study, we used vagal ganglia transcriptome profiling and connectivity mapping to identify compounds beneficial for alleviating airway hyperreactivity (AHR). As a comparison, we a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reznikov, Leah R., Meyerholz, David K., Abou Alaiwa, Mahmoud, Kuan, Shin-Ping, Liao, Yan-Shin J., Bormann, Nicholas L., Bair, Thomas B., Price, Margaret, Stoltz, David A., Welsh, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139658/ https://www.ncbi.nlm.nih.gov/pubmed/29631359 http://dx.doi.org/10.1152/ajplung.00557.2017

Ejemplares similares

Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice
por: Reznikov, Leah R., et al.
Publicado: (2016)

Constitutive Overexpression of Muscarinic Receptors Leads to Vagal Hyperreactivity
por: Livolsi, Angelo, et al.
Publicado: (2010)

Correction: Constitutive Overexpression of Muscarinic Receptors Leads to Vagal Hyperreactivity
por: Livolsi, Angelo, et al.
Publicado: (2011)

Unexpected sirolimus-stimulated airway hyperreactivity in lymphangioleiomyomatosis
por: Steagall, Wendy K., et al.
Publicado: (2023)

Glycogen depletion can increase the specificity of mucin detection in airway tissues
por: Meyerholz, David K., et al.
Publicado: (2018)

Mounier–Kuhn syndrome: a case of tracheal smooth muscle remodeling
por: Cook, Daniel P., et al.
Publicado: (2016)

Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling
por: Mao, Suifang, et al.
Publicado: (2018)

Antigen Sensitization Influences Organophosphorus Pesticide–Induced Airway Hyperreactivity
por: Proskocil, Becky J., et al.
Publicado: (2008)

Effects of Flavin7 on allergen induced hyperreactivity of airways
por: Franova, S, et al.
Publicado: (2009)

Insect Bite Hypersensitivity in Horses is Associated with Airway Hyperreactivity
por: Lanz, S., et al.
Publicado: (2017)

Baseline spirometry parameters as predictors of airway hyperreactivity in adults with suspected asthma
por: Peled, Michael, et al.
Publicado: (2021)

Virus memory induces airway hyperreactivity through eosinophil activation
por: Skappak, Christopher, et al.
Publicado: (2010)

Salvinorin A Inhibits Airway Hyperreactivity Induced by Ovalbumin Sensitization
por: Rossi, Antonietta, et al.
Publicado: (2017)

Association of childhood croup and increased incidence of airway hyperreactivity in adulthood
por: Modaresi, Mohammadreza, et al.
Publicado: (2018)

Glucagon reduces airway hyperreactivity, inflammation, and remodeling induced by ovalbumin
por: Insuela, Daniella B. R., et al.
Publicado: (2019)

Lack of airway submucosal glands impairs respiratory host defenses
por: Ostedgaard, Lynda S, et al.
Publicado: (2020)

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity
por: Evans, Christopher M., et al.
Publicado: (2015)

S-Nitrosoglutathione Reductase Inhibition Regulates Allergen-Induced Lung Inflammation and Airway Hyperreactivity
por: Ferrini, Maria E., et al.
Publicado: (2013)

Transduction of Pig Small Airway Epithelial Cells and Distal Lung Progenitor Cells by AAV4
por: Chen, Oliver G., et al.
Publicado: (2021)

Pediatric radiofrequency ablation of cardiac parasympathetic ganglia to achieve vagal denervation
por: Kumthekar, Rohan N., et al.
Publicado: (2020)

Myocardial infarction reduces cardiac nociceptive neurotransmission through the vagal ganglia
por: Salavatian, Siamak, et al.
Publicado: (2022)

Immunological characterisation of an acute murine model of lung inflammation and airway hyperreactivity
por: Dixon, Kate L, et al.
Publicado: (2013)

Calcium-Sensing Receptor and CPAP-Induced Neonatal Airway Hyperreactivity in Mice
por: Mayer, Catherine A, et al.
Publicado: (2022)

Effects of Diet-Induced Mild Obesity on Airway Hyperreactivity and Lung Inflammation in Mice
por: Jung, Sun Hee, et al.
Publicado: (2013)

Intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity in neonatal rats
por: Choi, Chang Won, et al.
Publicado: (2013)

Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
por: Galle-Treger, Lauriane, et al.
Publicado: (2016)

IL-13 is a central mediator of chemical-induced airway hyperreactivity in mice
por: Devos, Fien C., et al.
Publicado: (2017)

CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity
por: Kramer, Elizabeth L., et al.
Publicado: (2023)

Strategies for measuring airway mucus and mucins
por: Atanasova, Kalina R., et al.
Publicado: (2019)

Resveratrol has protective effects against airway remodeling and airway hyperreactivity in a murine model of allergic airways disease
por: Royce, Simon G., et al.
Publicado: (2011)

Attenuated Amiloride-Sensitive Current and Augmented Calcium-Activated Chloride Current in Marsh Rice Rat (Oryzomys palustris) Airways
por: Kuan, Shin-Ping, et al.
Publicado: (2019)

Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection
por: Eccles, R., et al.
Publicado: (2004)

Prevention of antigen-induced bronchial hyperreactivity and airway inflammation in sensitized guinea-pigs by tacrolimus.
por: Lapa e Silva, J R, et al.
Publicado: (1999)

Fish Oil Has Beneficial Effects on Allergen-Induced Airway Inflammation and Hyperreactivity in Mice
por: Bargut, Thereza Cristina Lonzetti, et al.
Publicado: (2013)

Assessment of airway hyperreactivity: comparison of forced spirometry and body plethysmography for methacholine challenge tests
por: Nensa, F, et al.
Publicado: (2009)

TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity
por: Hurrell, Benjamin P., et al.
Publicado: (2019)

CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation
por: Shafiei-Jahani, Pedram, et al.
Publicado: (2021)

Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung
por: Pezzulo, Alejandro A., et al.
Publicado: (2012)

Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs
por: Pino-Argumedo, Maria I., et al.
Publicado: (2022)

Tromethamine improves mucociliary clearance in cystic fibrosis pigs
por: Ash, Jamison J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ovbml3abq9hi8ck06fhvrrfkcq