A Luminal Loop of Wilson Disease Protein Binds Copper and Is Required for Protein Activity

The copper-transporting ATPase ATP7B is essential for loading of copper ions to copper-dependent enzymes in the secretory pathway; its inactivation results in Wilson disease. In contrast to copper-ion uptake by the cytoplasmic domains, ATP7B-mediated copper-ion release in the Golgi has not been expl...

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Detalles Bibliográficos
Autores principales: Köhn, Birgit, Ponnandai Shanmugavel, Kumaravel, Wu, Min, Kovermann, Michael, Wittung-Stafshede, Pernilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2018
Materias:
Proteins
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139820/
https://www.ncbi.nlm.nih.gov/pubmed/30173886
http://dx.doi.org/10.1016/j.bpj.2018.07.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139820/
https://www.ncbi.nlm.nih.gov/pubmed/30173886
http://dx.doi.org/10.1016/j.bpj.2018.07.040

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