Cargando…
A Luminal Loop of Wilson Disease Protein Binds Copper and Is Required for Protein Activity
The copper-transporting ATPase ATP7B is essential for loading of copper ions to copper-dependent enzymes in the secretory pathway; its inactivation results in Wilson disease. In contrast to copper-ion uptake by the cytoplasmic domains, ATP7B-mediated copper-ion release in the Golgi has not been expl...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139820/ https://www.ncbi.nlm.nih.gov/pubmed/30173886 http://dx.doi.org/10.1016/j.bpj.2018.07.040 |