Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin...

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Autores principales: Bandyopadhyay, Indrajit, Chowdhury, Sandipan Roy, Visavadiya, Nishant P., Hecht, Sidney M., Khdour, Omar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139889/
https://www.ncbi.nlm.nih.gov/pubmed/30225325
http://dx.doi.org/10.1016/j.dib.2018.08.156
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author Bandyopadhyay, Indrajit
Chowdhury, Sandipan Roy
Visavadiya, Nishant P.
Hecht, Sidney M.
Khdour, Omar M.
author_facet Bandyopadhyay, Indrajit
Chowdhury, Sandipan Roy
Visavadiya, Nishant P.
Hecht, Sidney M.
Khdour, Omar M.
author_sort Bandyopadhyay, Indrajit
collection PubMed
description As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich’s ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.
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spelling pubmed-61398892018-09-17 Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels Bandyopadhyay, Indrajit Chowdhury, Sandipan Roy Visavadiya, Nishant P. Hecht, Sidney M. Khdour, Omar M. Data Brief Chemistry As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich’s ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues. Elsevier 2018-08-31 /pmc/articles/PMC6139889/ /pubmed/30225325 http://dx.doi.org/10.1016/j.dib.2018.08.156 Text en © 2018 Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Chemistry
Bandyopadhyay, Indrajit
Chowdhury, Sandipan Roy
Visavadiya, Nishant P.
Hecht, Sidney M.
Khdour, Omar M.
Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels
title Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels
title_full Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels
title_fullStr Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels
title_full_unstemmed Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels
title_short Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels
title_sort chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139889/
https://www.ncbi.nlm.nih.gov/pubmed/30225325
http://dx.doi.org/10.1016/j.dib.2018.08.156
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