Cargando…

Dexmedetomidine Ameliorates Acute Stress-Induced Kidney Injury by Attenuating Oxidative Stress and Apoptosis through Inhibition of the ROS/JNK Signaling Pathway

Acute stress induces tissue damage through excessive oxidative stress. Dexmedetomidine (DEX) reportedly has an antioxidant effect. However, protective roles and related potential molecular mechanisms of DEX against kidney injury induced by acute stress are unknown. Herein, rats were forced to swim 1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yongping, Feng, Xiujing, Hu, Xueyuan, Sha, Jichen, Li, Bei, Zhang, Huayun, Fan, Honggang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140004/ https://www.ncbi.nlm.nih.gov/pubmed/30250633 http://dx.doi.org/10.1155/2018/4035310

Ejemplares similares

Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway
por: Zhao, Yuan, et al.
Publicado: (2020)

P-STAT3 Inhibition Activates Endoplasmic Reticulum Stress-Induced Splenocyte Apoptosis in Chronic Stress
por: Song, Manyu, et al.
Publicado: (2020)

Dexmedetomidine Attenuates Oxidative Stress Induced Lung Alveolar Epithelial Cell Apoptosis In Vitro
por: Cui, Jian, et al.
Publicado: (2015)

Chitosan-Coated Selenium Nanoparticles Attenuate PRRSV Replication and ROS/JNK-Mediated Apoptosis in vitro
por: Shao, Chunyan, et al.
Publicado: (2022)

DHA ameliorates MeHg-induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway
por: Zhang, Hong, et al.
Publicado: (2021)

Dexmedetomidine Pretreatment Attenuates Kidney Injury and Oxidative Stress during Orthotopic Autologous Liver Transplantation in Rats
por: Yu, Xiaofang, et al.
Publicado: (2016)

Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells
por: Ma, Jun, et al.
Publicado: (2015)

Dexmedetomidine attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress, mitochondrial dysfunction and apoptosis in rats
por: Fu, Chunlai, et al.
Publicado: (2017)

ALA/LA ameliorates glucose toxicity on HK-2 cells by attenuating oxidative stress and apoptosis through the ROS/p38/TGF-β(1) pathway
por: Jiang, Mingxia, et al.
Publicado: (2017)

Astaxanthin Attenuates Early Acute Kidney Injury Following Severe Burns in Rats by Ameliorating Oxidative Stress and Mitochondrial-Related Apoptosis
por: Guo, Song-Xue, et al.
Publicado: (2015)

Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stress
por: Liu, Zhongjie, et al.
Publicado: (2020)

Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling
por: Wang, Kang, et al.
Publicado: (2022)

Attenuation of the Na/K-ATPase/Src/ROS amplification signaling pathway by astaxanthin ameliorates myocardial cell oxidative stress injury
por: Qu, Xuefeng, et al.
Publicado: (2020)

Creatinine accelerates APAP-induced liver damage by increasing oxidative stress through ROS/JNK signaling pathway
por: Liu, Fang, et al.
Publicado: (2022)

Dexmedetomidine Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting p75NTR-Mediated Oxidative Stress and Apoptosis
por: Wang, Zhe, et al.
Publicado: (2020)

Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos
por: Xia, Qing, et al.
Publicado: (2021)

Dexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling
por: Yang, Yu-fan, et al.
Publicado: (2021)

Acacetin Induces Apoptosis in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation
por: Wang, Shubin, et al.
Publicado: (2020)

Andrographolide induces apoptosis in human osteosarcoma cells via the ROS/JNK pathway
por: Wang, Shengdong, et al.
Publicado: (2020)

Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury
por: Lempiäinen, Juha, et al.
Publicado: (2014)

Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma
por: Yang, Hongyan, et al.
Publicado: (2017)

Dexmedetomidine Protects against Myocardial Ischemia/Reperfusion Injury by Ameliorating Oxidative Stress and Cell Apoptosis through the Trx1-Dependent Akt Pathway
por: Wu, Zhi-lin, et al.
Publicado: (2020)

N-Acetylcysteine Attenuates Ischemia-Reperfusion-Induced Apoptosis and Autophagy in Mouse Liver via Regulation of the ROS/JNK/Bcl-2 Pathway
por: Wang, Chengfen, et al.
Publicado: (2014)

Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway
por: Park, Cheol, et al.
Publicado: (2019)

Nonylphenol Induces Apoptosis through ROS/JNK Signaling in a Spermatogonia Cell Line
por: Park, Hyun-Jung, et al.
Publicado: (2020)

Actin remodeling mediates ROS production and JNK activation to drive apoptosis-induced proliferation
por: Farrell, Luchi, et al.
Publicado: (2022)

Hyperhomocysteinemia exacerbates ischemia-reperfusion injury-induced acute kidney injury by mediating oxidative stress, DNA damage, JNK pathway, and apoptosis
por: Zhang, Mei, et al.
Publicado: (2021)

Curcumin Induced Human Gastric Cancer BGC-823 Cells Apoptosis by ROS-Mediated ASK1-MKK4-JNK Stress Signaling Pathway
por: Liang, Tao, et al.
Publicado: (2014)

Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway
por: Xiao, Shilin, et al.
Publicado: (2022)

Dexmedetomidine attenuates H(2)O(2)-induced neonatal rat cardiomyocytes apoptosis through mitochondria- and ER-medicated oxidative stress pathways
por: Liu, Xue-Ru, et al.
Publicado: (2018)

Dexmedetomidine Attenuates Apoptosis and Neurological Deficits by Modulating Neuronal NADPH Oxidase 2-Derived Oxidative Stress in Neonates Following Hypoxic Brain Injury
por: Chen, Xiaohui, et al.
Publicado: (2022)

Eupatilin Ameliorates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation, Oxidative Stress, and Apoptosis in Mice
por: Kim, Kiryeong, et al.
Publicado: (2023)

Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury
por: Yang, Tianyuan, et al.
Publicado: (2020)

Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney
por: Park, Chan Hum, et al.
Publicado: (2012)

Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation
por: Ilmarinen-Salo, Pinja, et al.
Publicado: (2012)

Notoginsenoside R1 attenuates oxidative stress‐induced osteoblast dysfunction through JNK signalling pathway
por: Li, Xumin, et al.
Publicado: (2021)

The Effect of Dexmedetomidine on Oxidative Stress during Pneumoperitoneum
por: Cekic, Bahanur, et al.
Publicado: (2014)

Dexmedetomidine Protects Cerebellar Neurons against Hyperoxia-Induced Oxidative Stress and Apoptosis in the Juvenile Rat
por: Puls, Robert, et al.
Publicado: (2023)

Spermidine Attenuates Oxidative Stress-Induced Apoptosis via Blocking Ca(2+) Overload in Retinal Pigment Epithelial Cells Independently of ROS
por: Kim, Da Hye, et al.
Publicado: (2021)

Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats
por: Al-Rasheed, Nawal M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dkhhq58uho2p25e1hkofsh8hsh