Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches

In certain structural or functional contexts, RNA structures can contain protonated nucleotides. However, a direct role for stably protonated nucleotides in ligand binding and ligand recognition has not yet been demonstrated unambiguously. Previous X-ray structures of c-GAMP binding riboswitch aptam...

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Detalles Bibliográficos
Autores principales: Keller, Heiko, Weickhmann, A. Katharina, Bock, Thomas, Wöhnert, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140456/
https://www.ncbi.nlm.nih.gov/pubmed/30006500
http://dx.doi.org/10.1261/rna.067470.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140456/
https://www.ncbi.nlm.nih.gov/pubmed/30006500
http://dx.doi.org/10.1261/rna.067470.118

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