Increasing the length of poly-pyrimidine bulges broadens RNA conformational ensembles with minimal impact on stacking energetics

Helical elements separated by bulges frequently undergo transitions between unstacked and coaxially stacked conformations during the folding and function of noncoding RNAs. Here, we examine the dynamic properties of poly-pyrimidine bulges of varying length (n = 1–4, 7) across a range of Mg(2+) conce...

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Detalles Bibliográficos
Autores principales: Merriman, Dawn K., Yuan, Jiayi, Shi, Honglue, Majumdar, Ananya, Herschlag, Daniel, Al-Hashimi, Hashim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140463/
https://www.ncbi.nlm.nih.gov/pubmed/30012568
http://dx.doi.org/10.1261/rna.066258.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140463/
https://www.ncbi.nlm.nih.gov/pubmed/30012568
http://dx.doi.org/10.1261/rna.066258.118

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