Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB p65 subunit

AIM: Mesangial cell (MC) activation plays an important role in many glomerular diseases associated with renal fibrosis, including diabetic kidney disease (DKD). The aim of this study was to determine whether Astragaloside IV (AS-IV) modulated MC activation in DKD via autophagy by specifically regula...

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Detalles Bibliográficos
Autores principales: Wang, Xiaolei, Gao, Yanbin, Tian, Nianxiu, Zhu, Zhiyao, Wang, Tao, Xu, Jiayi, Wu, Bingjie, Zhang, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140761/
https://www.ncbi.nlm.nih.gov/pubmed/30254426
http://dx.doi.org/10.2147/DDDT.S174058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140761/
https://www.ncbi.nlm.nih.gov/pubmed/30254426
http://dx.doi.org/10.2147/DDDT.S174058

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