Cargando…

Functional characteristics of novel pancreatic Pax6 regulatory elements

Complex diseases, such as diabetes, are influenced by comprehensive transcriptional networks. Genome-wide association studies have revealed that variants located in regulatory elements for pancreatic transcription factors are linked to diabetes, including those functionally linked to the paired box...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buckle, Adam, Nozawa, Ryu-suke, Kleinjan, Dirk A, Gilbert, Nick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140780/ https://www.ncbi.nlm.nih.gov/pubmed/30007277 http://dx.doi.org/10.1093/hmg/ddy255

Ejemplares similares

DNaseI Hypersensitivity and Ultraconservation Reveal Novel, Interdependent Long-Range Enhancers at the Complex Pax6 Cis-Regulatory Region
por: McBride, David J., et al.
Publicado: (2011)

Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse
por: Tyas, David A, et al.
Publicado: (2006)

Subfunctionalization of Duplicated Zebrafish pax6 Genes by cis-Regulatory Divergence
por: Kleinjan, Dirk A, et al.
Publicado: (2008)

Human centromere repositioning activates transcription and opens chromatin fibre structure
por: Naughton, Catherine, et al.
Publicado: (2022)

The Developmental Regulator Pax6 Is Essential for Maintenance of Islet Cell Function in the Adult Mouse Pancreas
por: Hart, Alan W., et al.
Publicado: (2013)

A Novel Pax5-Binding Regulatory Element in the Igκ Locus
por: Levin-Klein, Rena, et al.
Publicado: (2014)

Long-range downstream enhancers are essential for Pax6 expression
por: Kleinjan, Dirk A., et al.
Publicado: (2006)

Sequencing of Pax6 Loci from the Elephant Shark Reveals a Family of Pax6 Genes in Vertebrate Genomes, Forged by Ancient Duplications and Divergences
por: Ravi, Vydianathan, et al.
Publicado: (2013)

Lampreys, the jawless vertebrates, contain three Pax6 genes with distinct expression in eye, brain and pancreas
por: Ravi, Vydianathan, et al.
Publicado: (2019)

A conditional Pax6 depletion study with no morphological effect on the adult mouse corneal epithelium
por: Dorà, Natalie J., et al.
Publicado: (2018)

Identification of Genomic Regions Regulating Pax6 Expression in Embryonic Forebrain Using YAC Reporter Transgenic Mouse Lines
por: Mi, Da, et al.
Publicado: (2013)

Novel PAX6 variant in a family with ophthalmologic, pancreatic, and olfactory features
por: Buehne, Kristen L., et al.
Publicado: (2022)

Mapping gene regulatory circuitry of Pax6 during neurogenesis
por: Thakurela, Sudhir, et al.
Publicado: (2016)

Common Fragile Sites Are Characterized by Faulty Condensin Loading after Replication Stress
por: Boteva, Lora, et al.
Publicado: (2020)

Quantitative spatial and temporal assessment of regulatory element activity in zebrafish
por: Bhatia, Shipra, et al.
Publicado: (2021)

Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements
por: Vicente-García, Cristina, et al.
Publicado: (2017)

Identification of Pax6-Dependent Gene Regulatory Networks in the Mouse Lens
por: Wolf, Louise V., et al.
Publicado: (2009)

Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells
por: Pavlaki, Ioanna, et al.
Publicado: (2022)

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development
por: Sun, Jian, et al.
Publicado: (2015)

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis
por: Sansom, Stephen N., et al.
Publicado: (2009)

Correction: Identification of Pax6-Dependent Gene Regulatory Networks in the Mouse Lens
por: Wolf, Louise V., et al.
Publicado: (2009)

Mapping the Pax6 3’ untranslated region microRNA regulatory landscape
por: Ryan, Bridget C., et al.
Publicado: (2018)

Functional Characteristics of Diverse PAX6 Mutations Associated with Isolated Foveal Hypoplasia
por: Matsushita, Itsuka, et al.
Publicado: (2023)

Novel PAX6 mutation reported in an aniridia patient
por: Winegarner, Andrew, et al.
Publicado: (2017)

Marie Curie – Genome Architecture in Relation to Disease Conference 3 Higher Order Genome Architecture
por: Gilbert, Nick, et al.
Publicado: (2009)

Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality
por: Ushiki, Aki, et al.
Publicado: (2023)

SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs
por: Nozawa, Ryu-Suke, et al.
Publicado: (2017)

Relative roles of the different Pax6 domains for pancreatic alpha cell development
por: Dames, Petra, et al.
Publicado: (2010)

Canonical and alternative transcript expression of PAX6 and CXCR4 in pancreatic cancer
por: Little, Elizabeth C., et al.
Publicado: (2017)

Evolution of the Vertebrate Pax4/6 Class of Genes with Focus on Its Novel Member, the Pax10 Gene
por: Feiner, Nathalie, et al.
Publicado: (2014)

Impaired DNA-binding affinity of novel PAX6 mutations
por: Lee, Seowhang, et al.
Publicado: (2020)

Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay
por: Saha, Abhijit, et al.
Publicado: (2016)

Positive autoregulation of the transcription factor Pax6 in response to increased levels of either of its major isoforms, Pax6 or Pax6(5a), in cultured cells
por: Pinson, Jeni, et al.
Publicado: (2006)

Regulation of the Pax6 : Pax6(5a) mRNA ratio in the developing mammalian brain
por: Pinson, Jeni, et al.
Publicado: (2005)

Pax6 mutant cerebral organoids partially recapitulate phenotypes of Pax6 mutant mouse strains
por: Ferdaos, Nurfarhana, et al.
Publicado: (2022)

PAX6 disease models for aniridia
por: Abdolkarimi, Dorsa, et al.
Publicado: (2022)

Novel clinical presentation and PAX6 mutation in families with congenital aniridia
por: Guo, Ruru, et al.
Publicado: (2022)

PAX6 Regulates Melanogenesis in the Retinal Pigmented Epithelium through Feed-Forward Regulatory Interactions with MITF
por: Raviv, Shaul, et al.
Publicado: (2014)

The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6
por: Antosova, Barbora, et al.
Publicado: (2016)

Remotely acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD
por: Mayes, Mary B., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_n21tldkgjl9o78eli2v7d7rks6