JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BET protein association to histone H4-hyperacetylate...

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Detalles Bibliográficos
Autores principales: Handoko, Lusy, Kaczkowski, Bogumil, Hon, Chung-Chau, Lizio, Marina, Wakamori, Masatoshi, Matsuda, Takayoshi, Ito, Takuhiro, Jeyamohan, Prashanti, Sato, Yuko, Sakamoto, Kensaku, Yokoyama, Shigeyuki, Kimura, Hiroshi, Minoda, Aki, Umehara, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140815/
https://www.ncbi.nlm.nih.gov/pubmed/30080437
http://dx.doi.org/10.1080/15592294.2018.1469891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140815/
https://www.ncbi.nlm.nih.gov/pubmed/30080437
http://dx.doi.org/10.1080/15592294.2018.1469891

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