Subcellular origin of mitochondrial DNA deletions in human skeletal muscle

OBJECTIVE: In patients with mitochondrial DNA (mtDNA) maintenance disorders and with aging, mtDNA deletions sporadically form and clonally expand within individual muscle fibers, causing respiratory chain deficiency. This study aimed to identify the sub‐cellular origin and potential mechanisms under...

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Detalles Bibliográficos
Autores principales: Vincent, Amy E., Rosa, Hannah S., Pabis, Kamil, Lawless, Conor, Chen, Chun, Grünewald, Anne, Rygiel, Karolina A., Rocha, Mariana C., Reeve, Amy K., Falkous, Gavin, Perissi, Valentina, White, Kathryn, Davey, Tracey, Petrof, Basil J., Sayer, Avan A., Cooper, Cyrus, Deehan, David, Taylor, Robert W., Turnbull, Doug M., Picard, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141001/
https://www.ncbi.nlm.nih.gov/pubmed/30014514
http://dx.doi.org/10.1002/ana.25288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141001/
https://www.ncbi.nlm.nih.gov/pubmed/30014514
http://dx.doi.org/10.1002/ana.25288

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