Cargando…

Subcellular origin of mitochondrial DNA deletions in human skeletal muscle

OBJECTIVE: In patients with mitochondrial DNA (mtDNA) maintenance disorders and with aging, mtDNA deletions sporadically form and clonally expand within individual muscle fibers, causing respiratory chain deficiency. This study aimed to identify the sub‐cellular origin and potential mechanisms under...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vincent, Amy E., Rosa, Hannah S., Pabis, Kamil, Lawless, Conor, Chen, Chun, Grünewald, Anne, Rygiel, Karolina A., Rocha, Mariana C., Reeve, Amy K., Falkous, Gavin, Perissi, Valentina, White, Kathryn, Davey, Tracey, Petrof, Basil J., Sayer, Avan A., Cooper, Cyrus, Deehan, David, Taylor, Robert W., Turnbull, Doug M., Picard, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141001/ https://www.ncbi.nlm.nih.gov/pubmed/30014514 http://dx.doi.org/10.1002/ana.25288

Ejemplares similares

Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network
por: Vincent, Amy E., et al.
Publicado: (2019)

Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network
por: Vincent, Amy E., et al.
Publicado: (2019)

The rise and rise of mitochondrial DNA mutations
por: Lawless, Conor, et al.
Publicado: (2020)

The ageing neuromuscular system and sarcopenia: a mitochondrial perspective
por: Rygiel, Karolina A., et al.
Publicado: (2016)

Mitochondrial DNA Depletion in Respiratory Chain–Deficient Parkinson Disease Neurons
por: Grünewald, Anne, et al.
Publicado: (2016)

Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue
por: Grünewald, Anne, et al.
Publicado: (2014)

Complex mitochondrial DNA rearrangements in individual cells from patients with sporadic inclusion body myositis
por: Rygiel, Karolina A., et al.
Publicado: (2016)

Decoding mitochondrial heterogeneity in single muscle fibres by imaging mass cytometry
por: Warren, Charlotte, et al.
Publicado: (2020)

A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis
por: Rocha, Mariana C., et al.
Publicado: (2015)

The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy
por: Vincent, Amy E., et al.
Publicado: (2016)

Respiratory chain deficiency in aged spinal motor neurons()
por: Rygiel, Karolina A., et al.
Publicado: (2014)

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?()
por: Reeve, Amy, et al.
Publicado: (2014)

A subcellular cookie cutter for spatial genomics in human tissue
por: Bury, Alexander G., et al.
Publicado: (2022)

Triplex real-time PCR–an improved method to detect a wide spectrum of mitochondrial DNA deletions in single cells
por: Rygiel, Karolina A., et al.
Publicado: (2015)

Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence?
por: Chen, Chun, et al.
Publicado: (2019)

Mitochondrial Mutations: Newly Discovered Players in Neuronal Degeneration
por: Lax, Nichola Z., et al.
Publicado: (2011)

Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo
por: Russell, Oliver M., et al.
Publicado: (2018)

No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis
por: Campbell, Graham R, et al.
Publicado: (2013)

Skeletal muscle mitochondrial oxidative phosphorylation function in idiopathic pulmonary arterial hypertension: in vivo and in vitro study
por: Sithamparanathan, Sasiharan, et al.
Publicado: (2018)

Mitochondrial dysfunction in myofibrillar myopathy
por: Vincent, Amy E., et al.
Publicado: (2016)

The ageing mitochondrial genome
por: Krishnan, Kim J., et al.
Publicado: (2007)

Nutrition and Sarcopenia: A Review of the Evidence and Implications for Preventive Strategies
por: Robinson, Siân, et al.
Publicado: (2012)

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss
por: Dobson, Philip F., et al.
Publicado: (2020)

Framingham cardiovascular disease risk scores and incident frailty: the English longitudinal study of ageing
por: Gale, Catharine R., et al.
Publicado: (2014)

Prevalence and risk factors for falls in older men and women: The English Longitudinal Study of Ageing
por: Gale, Catharine R., et al.
Publicado: (2016)

Dysferlin mutations and mitochondrial dysfunction
por: Vincent, Amy E., et al.
Publicado: (2016)

Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level
por: Lehmann, Diana, et al.
Publicado: (2019)

3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus
por: Faitg, Julie, et al.
Publicado: (2021)

Mitochondrial and inflammatory changes in sporadic inclusion body myositis
por: Rygiel, Karolina A., et al.
Publicado: (2015)

Mitochondrial Nanotunnels
por: Vincent, Amy E., et al.
Publicado: (2017)

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
por: Campbell, Graham R, et al.
Publicado: (2011)

Diaphragmatic dysfunction in the intensive care unit: caught in the cross-fire between sepsis and mechanical ventilation
por: Petrof, Basil J
Publicado: (2013)

Prevention and optimal management of sarcopenia: a review of combined exercise and nutrition interventions to improve muscle outcomes in older people
por: Denison, Hayley J, et al.
Publicado: (2015)

Linking the Metabolic State and Mitochondrial DNA in Chronic Disease, Health, and Aging
por: Picard, Martin, et al.
Publicado: (2013)

Subcellular western blotting of single cells
por: Yamauchi, Kevin A., et al.
Publicado: (2017)

Elevated metallothionein expression in long-lived species
por: Malavolta, Marco, et al.
Publicado: (2022)

Growth in early life predicts bone strength in late adulthood: The Hertfordshire Cohort Study
por: Oliver, Helen, et al.
Publicado: (2007)

The dynamic relationship between cognitive function and walking speed: the English Longitudinal Study of Ageing
por: Gale, Catharine R, et al.
Publicado: (2014)

Accumulation of risk factors associated with poor bone health in older adults
por: Zhang, Jean, et al.
Publicado: (2015)

Personality and Risk of Frailty: the English Longitudinal Study of Ageing
por: Gale, Catharine R, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_8sfiimba507h7307nn1nm4j47v