Cargando…
The Shieldin complex mediates 53BP1-dependent DNA repair
53BP1 is a chromatin-binding protein that regulates DNA double-strand break (DSB) repair by suppressing the nucleolytic resection of DNA termini1,2. This function of 53BP1 requires interactions with PTIP3 and RIF14–9, the latter also recruiting REV7/MAD2L2 to break sites10,11. How 53BP1-pathway prot...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141009/ https://www.ncbi.nlm.nih.gov/pubmed/30022168 http://dx.doi.org/10.1038/s41586-018-0340-7 |