Prespliceosome structure provides insights into spliceosome assembly and regulation

The spliceosome catalyzes the excision of introns from pre-mRNA in two steps, branching and exon ligation, and is assembled from five small nuclear ribonucleoprotein particles (snRNPs; U1, U2, U4, U5, U6) and numerous non-snRNP factors1. For branching, the intron 5'-splice site (5'SS) and...

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Detalles Bibliográficos
Autores principales: Plaschka, Clemens, Lin, Pei-Chun, Charenton, Clément, Nagai, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141012/
https://www.ncbi.nlm.nih.gov/pubmed/29995849
http://dx.doi.org/10.1038/s41586-018-0323-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141012/
https://www.ncbi.nlm.nih.gov/pubmed/29995849
http://dx.doi.org/10.1038/s41586-018-0323-8

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