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Destabilization of the von Willebrand factor A2 domain under oxidizing conditions investigated by molecular dynamics simulations
The protein von Willebrand factor (VWF) is key for the adhesion of blood platelets to sites of vascular injury. Recent studies have shown that the release of oxidative agents during inflammation increases the platelet-tethering activity of VWF contributing to a pro-thrombotic state. This has been li...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141083/ https://www.ncbi.nlm.nih.gov/pubmed/30222754 http://dx.doi.org/10.1371/journal.pone.0203675 |