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Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2
OBJECTIVE: To explore the anti-inflammatory mechanism of IGF1R inhibitor in diabetic nephropathy. METHODS: C57/BL6 mice were reared with high-fat diet for 8 weeks, then were injected 30 mg/kg streptozotocin intraperitoneally to induce type 2 diabetes. After 8 weeks, the type 2 diabetes nephropathy m...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141121/ https://www.ncbi.nlm.nih.gov/pubmed/30254418 http://dx.doi.org/10.2147/DDDT.S171638 |