Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ

The hepatic glucose fasting response is gaining traction as a therapeutic pathway to enhance hepatic and whole-host metabolism. However, the mechanisms underlying these metabolic effects remain unclear. Here, we demonstrate the epidermal-type lipoxygenase, eLOX3 (encoded by its gene, Aloxe3), is a p...

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Detalles Bibliográficos
Autores principales: Higgins, Cassandra B., Zhang, Yiming, Mayer, Allyson L., Fujiwara, Hideji, Stothard, Alicyn I., Graham, Mark J., Swarts, Benjamin M., DeBosch, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141168/
https://www.ncbi.nlm.nih.gov/pubmed/30135298
http://dx.doi.org/10.1172/jci.insight.120794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141168/
https://www.ncbi.nlm.nih.gov/pubmed/30135298
http://dx.doi.org/10.1172/jci.insight.120794

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