Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress

Encoded by EEF1A1, the eukaryotic translation elongation factor eEF1α1 strongly promotes the heat shock response, which protects cancer cells from proteotoxic stress, following for instance oxidative stress, hypoxia or aneuploidy. Unexpectedly, therefore, we find that EEF1A1 mRNA levels are reduced...

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Detalles Bibliográficos
Autores principales: Lin, Cheng-Yu, Beattie, Alexandra, Baradaran, Behzad, Dray, Eloise, Duijf, Pascal H. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141510/
https://www.ncbi.nlm.nih.gov/pubmed/30224719
http://dx.doi.org/10.1038/s41598-018-32272-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141510/
https://www.ncbi.nlm.nih.gov/pubmed/30224719
http://dx.doi.org/10.1038/s41598-018-32272-x

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