The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes

Integration-defective lentiviral vectors (IDLVs) have become an important alternative tool for gene therapy applications and basic research. Unfortunately, IDLVs show lower transgene expression as compared to their integrating counterparts. In this study, we aimed to improve the expression levels of...

Descripción completa

Detalles Bibliográficos
Autores principales: Sánchez-Hernández, Sabina, Gutierrez-Guerrero, Alejandra, Martín-Guerra, Rocío, Cortijo-Gutierrez, Marina, Tristán-Manzano, María, Rodriguez-Perales, Sandra, Sanchez, Laura, Garcia-Perez, Jose Luis, Chato-Astrain, Jesus, Fernandez-Valades, Ricardo, Carrillo-Galvez, Ana Belén, Anderson, Per, Montes, Rosa, Real, Pedro J., Martin, Francisco, Benabdellah, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141704/
https://www.ncbi.nlm.nih.gov/pubmed/30227274
http://dx.doi.org/10.1016/j.omtn.2018.08.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141704/
https://www.ncbi.nlm.nih.gov/pubmed/30227274
http://dx.doi.org/10.1016/j.omtn.2018.08.007

Ejemplares similares