Dealing With BRCA1/2 Unclassified Variants in a Cancer Genetics Clinic: Does Cosegregation Analysis Help?

Background: Detection of variants of uncertain significance (VUSs) in BRCA1 and BRCA2 genes poses relevant challenges for counseling and managing patients. VUS carriers should be managed similarly to probands with no BRCA1/2 variants detected, and predictive genetic testing in relatives is discourag...

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Detalles Bibliográficos
Autores principales: Zuntini, Roberta, Ferrari, Simona, Bonora, Elena, Buscherini, Francesco, Bertonazzi, Benedetta, Grippa, Mina, Godino, Lea, Miccoli, Sara, Turchetti, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141711/
https://www.ncbi.nlm.nih.gov/pubmed/30254663
http://dx.doi.org/10.3389/fgene.2018.00378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141711/
https://www.ncbi.nlm.nih.gov/pubmed/30254663
http://dx.doi.org/10.3389/fgene.2018.00378

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