Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial
Nausea and vomiting are among the most common and distressing side effects of chemotherapy. Additional antiemetic drugs are urgently needed to effectively manage and ameliorate chemotherapy-induced nausea and vomiting (CINV). The efficacy of ginger as an antiemetic modality for ameliorating CINV has...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142108/ https://www.ncbi.nlm.nih.gov/pubmed/29417850 http://dx.doi.org/10.1177/1534735417753541 |
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author | Li, Xiangfeng Qin, Ying Liu, Wei Zhou, Xiao-yu Li, Ya-nan Wang, Li-ying |
author_facet | Li, Xiangfeng Qin, Ying Liu, Wei Zhou, Xiao-yu Li, Ya-nan Wang, Li-ying |
author_sort | Li, Xiangfeng |
collection | PubMed |
description | Nausea and vomiting are among the most common and distressing side effects of chemotherapy. Additional antiemetic drugs are urgently needed to effectively manage and ameliorate chemotherapy-induced nausea and vomiting (CINV). The efficacy of ginger as an antiemetic modality for ameliorating CINV has not been established in previous studies. The aim of this study was to examine the efficacy of ginger, as an adjuvant drug to standard antiemetic therapy, in ameliorating acute and delayed CINV in patients with lung cancer receiving cisplatin-based regimens. In this randomized, double-blind, placebo-controlled clinical trial, 140 patients with lung cancer receiving cisplatin-based regimens were enrolled and allocated to receive either ginger root powder or a placebo. Ginger root powder was administered orally (0.5 g, 2 capsules per day, 0.25 g per capsule, every 12 hours) for 5 days beginning on the first day of chemotherapy. The incidence and severity of acute and delayed nausea and vomiting were assessed using the MASCC (Multinational Association for Supportive Care in Cancer) Antiemesis Tool (MAT). Adverse effects and patient adherence were also assessed in this study. No significant difference was observed between the ginger and control groups in the reduction of the incidence and severity of nausea and vomiting (P > .05). No significant difference in adverse events was observed between the 2 groups (P > .05). No study-treatment-related adverse events were observed in this study. As an adjuvant drug to standard antiemetic therapy, ginger had no additional efficacy in ameliorating CINV in patients with lung cancer receiving cisplatin-based regimens. |
format | Online Article Text |
id | pubmed-6142108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-61421082018-09-20 Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial Li, Xiangfeng Qin, Ying Liu, Wei Zhou, Xiao-yu Li, Ya-nan Wang, Li-ying Integr Cancer Ther Research Articles Nausea and vomiting are among the most common and distressing side effects of chemotherapy. Additional antiemetic drugs are urgently needed to effectively manage and ameliorate chemotherapy-induced nausea and vomiting (CINV). The efficacy of ginger as an antiemetic modality for ameliorating CINV has not been established in previous studies. The aim of this study was to examine the efficacy of ginger, as an adjuvant drug to standard antiemetic therapy, in ameliorating acute and delayed CINV in patients with lung cancer receiving cisplatin-based regimens. In this randomized, double-blind, placebo-controlled clinical trial, 140 patients with lung cancer receiving cisplatin-based regimens were enrolled and allocated to receive either ginger root powder or a placebo. Ginger root powder was administered orally (0.5 g, 2 capsules per day, 0.25 g per capsule, every 12 hours) for 5 days beginning on the first day of chemotherapy. The incidence and severity of acute and delayed nausea and vomiting were assessed using the MASCC (Multinational Association for Supportive Care in Cancer) Antiemesis Tool (MAT). Adverse effects and patient adherence were also assessed in this study. No significant difference was observed between the ginger and control groups in the reduction of the incidence and severity of nausea and vomiting (P > .05). No significant difference in adverse events was observed between the 2 groups (P > .05). No study-treatment-related adverse events were observed in this study. As an adjuvant drug to standard antiemetic therapy, ginger had no additional efficacy in ameliorating CINV in patients with lung cancer receiving cisplatin-based regimens. SAGE Publications 2018-02-08 /pmc/articles/PMC6142108/ /pubmed/29417850 http://dx.doi.org/10.1177/1534735417753541 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Articles Li, Xiangfeng Qin, Ying Liu, Wei Zhou, Xiao-yu Li, Ya-nan Wang, Li-ying Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial |
title | Efficacy of Ginger in Ameliorating Acute and Delayed
Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer
Receiving Cisplatin-Based Regimens: A Randomized Controlled
Trial |
title_full | Efficacy of Ginger in Ameliorating Acute and Delayed
Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer
Receiving Cisplatin-Based Regimens: A Randomized Controlled
Trial |
title_fullStr | Efficacy of Ginger in Ameliorating Acute and Delayed
Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer
Receiving Cisplatin-Based Regimens: A Randomized Controlled
Trial |
title_full_unstemmed | Efficacy of Ginger in Ameliorating Acute and Delayed
Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer
Receiving Cisplatin-Based Regimens: A Randomized Controlled
Trial |
title_short | Efficacy of Ginger in Ameliorating Acute and Delayed
Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer
Receiving Cisplatin-Based Regimens: A Randomized Controlled
Trial |
title_sort | efficacy of ginger in ameliorating acute and delayed
chemotherapy-induced nausea and vomiting among patients with lung cancer
receiving cisplatin-based regimens: a randomized controlled
trial |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142108/ https://www.ncbi.nlm.nih.gov/pubmed/29417850 http://dx.doi.org/10.1177/1534735417753541 |
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