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FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1α

The N-terminal acetyltransferase A (NatA) complex, which is composed of NAA10 and NAA15, catalyzes N-terminal acetylation of many proteins in a co-translational manner. Structurally, the catalytic subunit NAA10 was believed to have no activity toward an internal lysine residue because the gate of it...

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Detalles Bibliográficos
Autores principales: Kang, Jengmin, Chun, Yang-Sook, Huh, June, Park, Jong-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142190/
https://www.ncbi.nlm.nih.gov/pubmed/30237125
http://dx.doi.org/10.1016/j.redox.2018.09.002