Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I

The stereoselective total synthesis of strongylodiol H and I has been accomplished. The synthetic procedure comprised the stereoselective reduction of a ketone functionality in an ene–yne–one employing CBS as a catalyst and a Cadiot–Chodkiewicz coupling reaction as the key reaction steps. A common a...

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Autores principales: Gangadhar, Pamarthi, Ramakrishna, Sayini, Venkateswarlu, Ponneri, Srihari, Pabbaraja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142741/
https://www.ncbi.nlm.nih.gov/pubmed/30254695
http://dx.doi.org/10.3762/bjoc.14.206
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author Gangadhar, Pamarthi
Ramakrishna, Sayini
Venkateswarlu, Ponneri
Srihari, Pabbaraja
author_facet Gangadhar, Pamarthi
Ramakrishna, Sayini
Venkateswarlu, Ponneri
Srihari, Pabbaraja
author_sort Gangadhar, Pamarthi
collection PubMed
description The stereoselective total synthesis of strongylodiol H and I has been accomplished. The synthetic procedure comprised the stereoselective reduction of a ketone functionality in an ene–yne–one employing CBS as a catalyst and a Cadiot–Chodkiewicz coupling reaction as the key reaction steps. A common aldehyde intermediate has been used for the synthesis of both strongylodiols.
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spelling pubmed-61427412018-09-25 Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I Gangadhar, Pamarthi Ramakrishna, Sayini Venkateswarlu, Ponneri Srihari, Pabbaraja Beilstein J Org Chem Full Research Paper The stereoselective total synthesis of strongylodiol H and I has been accomplished. The synthetic procedure comprised the stereoselective reduction of a ketone functionality in an ene–yne–one employing CBS as a catalyst and a Cadiot–Chodkiewicz coupling reaction as the key reaction steps. A common aldehyde intermediate has been used for the synthesis of both strongylodiols. Beilstein-Institut 2018-09-04 /pmc/articles/PMC6142741/ /pubmed/30254695 http://dx.doi.org/10.3762/bjoc.14.206 Text en Copyright © 2018, Gangadhar et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Gangadhar, Pamarthi
Ramakrishna, Sayini
Venkateswarlu, Ponneri
Srihari, Pabbaraja
Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I
title Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I
title_full Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I
title_fullStr Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I
title_full_unstemmed Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I
title_short Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I
title_sort stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols h and i
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142741/
https://www.ncbi.nlm.nih.gov/pubmed/30254695
http://dx.doi.org/10.3762/bjoc.14.206
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AT ramakrishnasayini stereoselectivetotalsynthesisandstructuralrevisionofthediacetylenicdiolnaturalproductsstrongylodiolshandi
AT venkateswarluponneri stereoselectivetotalsynthesisandstructuralrevisionofthediacetylenicdiolnaturalproductsstrongylodiolshandi
AT sriharipabbaraja stereoselectivetotalsynthesisandstructuralrevisionofthediacetylenicdiolnaturalproductsstrongylodiolshandi

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