A novel and practical asymmetric synthesis of eptazocine hydrobromide

In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in...

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Autores principales: Li, Ruipeng, Liu, Zhenren, Chen, Liang, Pan, Jing, Lin, Kuaile, Zhou, Weicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142761/
https://www.ncbi.nlm.nih.gov/pubmed/30254698
http://dx.doi.org/10.3762/bjoc.14.209
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author Li, Ruipeng
Liu, Zhenren
Chen, Liang
Pan, Jing
Lin, Kuaile
Zhou, Weicheng
author_facet Li, Ruipeng
Liu, Zhenren
Chen, Liang
Pan, Jing
Lin, Kuaile
Zhou, Weicheng
author_sort Li, Ruipeng
collection PubMed
description In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in excellent overall yield and purity.
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spelling pubmed-61427612018-09-25 A novel and practical asymmetric synthesis of eptazocine hydrobromide Li, Ruipeng Liu, Zhenren Chen, Liang Pan, Jing Lin, Kuaile Zhou, Weicheng Beilstein J Org Chem Full Research Paper In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in excellent overall yield and purity. Beilstein-Institut 2018-09-06 /pmc/articles/PMC6142761/ /pubmed/30254698 http://dx.doi.org/10.3762/bjoc.14.209 Text en Copyright © 2018, Li et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Li, Ruipeng
Liu, Zhenren
Chen, Liang
Pan, Jing
Lin, Kuaile
Zhou, Weicheng
A novel and practical asymmetric synthesis of eptazocine hydrobromide
title A novel and practical asymmetric synthesis of eptazocine hydrobromide
title_full A novel and practical asymmetric synthesis of eptazocine hydrobromide
title_fullStr A novel and practical asymmetric synthesis of eptazocine hydrobromide
title_full_unstemmed A novel and practical asymmetric synthesis of eptazocine hydrobromide
title_short A novel and practical asymmetric synthesis of eptazocine hydrobromide
title_sort novel and practical asymmetric synthesis of eptazocine hydrobromide
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142761/
https://www.ncbi.nlm.nih.gov/pubmed/30254698
http://dx.doi.org/10.3762/bjoc.14.209
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