Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model

APP (amyloid precursor protein), the causative molecule of Alzheimer's disease, is synthesized in neuronal cell bodies and subsequently transported to synapses. We previously showed that the yata gene is required for the synaptic transport of the APP orthologue in Drosophila melanogaster. In th...

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Detalles Bibliográficos
Autores principales: Furotani, Koto, Kamimura, Keisuke, Yajima, Takaaki, Nakayama, Minoru, Enomoto, Rena, Tamura, Takuya, Okazawa, Hitoshi, Sone, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143267/
https://www.ncbi.nlm.nih.gov/pubmed/30226901
http://dx.doi.org/10.1371/journal.pone.0204048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143267/
https://www.ncbi.nlm.nih.gov/pubmed/30226901
http://dx.doi.org/10.1371/journal.pone.0204048

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