15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

Gout arthritis (GA) is a painful inflammatory disease in response to monosodium urate (MSU) crystals in the joints. 15deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a natural activator of PPAR-γ with analgesic, anti-inflammatory, and pro-resolution properties. Thus, we aimed to evaluate the effec...

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Detalles Bibliográficos
Autores principales: Ruiz-Miyazawa, Kenji W., Staurengo-Ferrari, Larissa, Pinho-Ribeiro, Felipe A., Fattori, Victor, Zaninelli, Tiago H., Badaro-Garcia, Stephanie, Borghi, Sergio M., Andrade, Ketlem C., Clemente-Napimoga, Juliana T., Alves-Filho, Jose C., Cunha, Thiago M., Fraceto, Leonardo F., Cunha, Fernando Q., Napimoga, Marcelo H., Casagrande, Rubia, Verri, Waldiceu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143605/
https://www.ncbi.nlm.nih.gov/pubmed/30228306
http://dx.doi.org/10.1038/s41598-018-32334-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143605/
https://www.ncbi.nlm.nih.gov/pubmed/30228306
http://dx.doi.org/10.1038/s41598-018-32334-0

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