Cargando…

The Mitochondrial Ca(2+) Uniporter Complex (MCUC) of Trypanosoma brucei Is a Hetero-oligomer That Contains Novel Subunits Essential for Ca(2+) Uptake

The mitochondrial calcium uniporter complex (MCUC) is a highly selective channel that conducts calcium ions across the organelle inner membrane. We previously characterized Trypanosoma brucei’s MCU (TbMCU) as an essential component of the MCUC required for parasite viability and infectivity. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Guozhong, Docampo, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143741/ https://www.ncbi.nlm.nih.gov/pubmed/30228243 http://dx.doi.org/10.1128/mBio.01700-18

Ejemplares similares

Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter
por: Huang, Guozhong, et al.
Publicado: (2013)

Functional analysis and importance for host cell infection of the Ca(2+)-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2019)

The Mitochondrial Calcium Uniporter Interacts with Subunit c of the ATP Synthase of Trypanosomes and Humans
por: Huang, Guozhong, et al.
Publicado: (2020)

Structural characterization of the mitochondrial Ca(2+) uniporter provides insights into Ca(2+) uptake and regulation
por: Wu, Wenping, et al.
Publicado: (2021)

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca(2+) Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi
por: Bertolini, Mayara S., et al.
Publicado: (2019)

Proteomic analysis of acidocalcisomes of Trypanosoma brucei uncovers their role in phosphate metabolism, cation homeostasis, and calcium signaling
por: Huang, Guozhong, et al.
Publicado: (2015)

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2017)

Pyrophosphate Stimulates the Phosphate-Sodium Symporter of Trypanosoma brucei Acidocalcisomes and Saccharomyces cerevisiae Vacuoles
por: Potapenko, Evgeniy, et al.
Publicado: (2019)

Characterization of Membrane Potential Dependency of Mitochondrial Ca(2+) Uptake by an Improved Biophysical Model of Mitochondrial Ca(2+) Uniporter
por: Pradhan, Ranjan K., et al.
Publicado: (2010)

An X-Domain Phosphoinositide Phospholipase C (PI-PLC-like) of Trypanosoma brucei Has a Surface Localization and Is Essential for Proliferation
por: Negrão, Núria W., et al.
Publicado: (2023)

Acidocalcisome-Mitochondrion Membrane Contact Sites in Trypanosoma brucei
por: Ramakrishnan, Srinivasan, et al.
Publicado: (2018)

Structural basis of Ca(2+) uptake by mitochondrial calcium uniporter in mitochondria: a brief review
por: Yoo, Jiho
Publicado: (2022)

Evaluation of In Vitro Activity of Essential Oils against Trypanosoma brucei brucei and Trypanosoma evansi
por: Habila, Nathan, et al.
Publicado: (2010)

An Essential Farnesylated Kinesin in Trypanosoma brucei
por: Engelson, Erin J., et al.
Publicado: (2011)

Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling Ca(2+) entry
por: Zhang, Lu yao, et al.
Publicado: (2021)

Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca(2+) uptake in photoreceptor mitochondria
por: Bisbach, Celia M., et al.
Publicado: (2020)

The F(0)F(1)-ATP Synthase Complex Contains Novel Subunits and Is Essential for Procyclic Trypanosoma brucei
por: Zíková, Alena, et al.
Publicado: (2009)

The Mitochondrial Ca(2+) uniporter is a central regulator of interorganellar Ca(2+) transfer and NFAT activation
por: Yoast, Ryan E., et al.
Publicado: (2021)

Mitochondrial pharmacology turns its sights on the Ca(2+) uniporter
por: Storey, Nina M, et al.
Publicado: (2017)

The mechanism of MICU-dependent gating of the mitochondrial Ca(2+)uniporter
por: Garg, Vivek, et al.
Publicado: (2021)

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector
por: Mantilla, Brian S., et al.
Publicado: (2017)

Mitochondrial Ca(2+) Uptake 1 (MICU1) and Mitochondrial Ca(2+) Uniporter (MCU) Contribute to Metabolism-Secretion Coupling in Clonal Pancreatic β-Cells
por: Alam, Muhammad Rizwan, et al.
Publicado: (2012)

Different Sensitivity of Control and MICU1- and MICU2-Ablated Trypanosoma cruzi Mitochondrial Calcium Uniporter Complex to Ruthenium-Based Inhibitors
por: Bertolini, Mayara S., et al.
Publicado: (2020)

The Mitochondrial Ca(2+) Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells
por: Tarasov, Andrei I., et al.
Publicado: (2012)

Distinct Effects of Mitochondrial Na(+)/Ca(2+) Exchanger Inhibition and Ca(2+) Uniporter Activation on Ca(2+) Sparks and Arrhythmogenesis in Diabetic Rats
por: Velmurugan, Sathya, et al.
Publicado: (2023)

Arginine and Lysine Transporters Are Essential for Trypanosoma brucei
por: Mathieu, Christoph, et al.
Publicado: (2017)

The mitochondrial Ca(2+) uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca(2+) oscillations
por: Patel, Akshar, et al.
Publicado: (2022)

Modulation of the mitochondrial Ca(2+) uniporter complex subunit expression by different shear stress patterns in vascular endothelial cells
por: Patel, Akshar, et al.
Publicado: (2023)

Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei
por: Macedo, Juan P., et al.
Publicado: (2017)

KREX2 Is Not Essential for Either Procyclic or Bloodstream Form Trypanosoma brucei
por: Carnes, Jason, et al.
Publicado: (2012)

MCU (mitochondrial Ca(2+) uniporter) makes the calcium go round
por: Walters, Grant C., et al.
Publicado: (2022)

Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane
por: Bondarenko, Alexander I., et al.
Publicado: (2013)

Metabolic adaptation to the chronic loss of Ca(2+) signaling induced by KO of IP(3) receptors or the mitochondrial Ca(2+) uniporter
por: Young, Michael P., et al.
Publicado: (2021)

Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei()
por: Urbaniak, Michael D.
Publicado: (2009)

Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2
por: Wang, Chongyuan, et al.
Publicado: (2020)

Structural insights into the Ca(2+)-dependent gating of the human mitochondrial calcium uniporter
por: Wang, Yan, et al.
Publicado: (2020)

The whole‐cell Ca(2+) release‐activated Ca(2+) current, I (CRAC), is regulated by the mitochondrial Ca(2+) uniporter channel and is independent of extracellular and cytosolic Na(+)
por: Samanta, Krishna, et al.
Publicado: (2019)

The pore-forming subunit MCU of the mitochondrial Ca(2+) uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice
por: Georgiadou, Eleni, et al.
Publicado: (2020)

Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca(2+) Oscillations, Store-Operated Ca(2+) Entry and Ca(2+)-Dependent Gene Expression in Response to Receptor Stimulation
por: Samanta, Krishna, et al.
Publicado: (2014)

Stepwise design of pseudosymmetric protein hetero-oligomers
por: Kibler, Ryan D., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_s08sej7gc4i427knh24u7opfjb