Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

Functional redundancy shared by paralog genes may afford protection against genetic perturbations, but it can also result in genetic vulnerabilities due to mutual interdependency(1–5). Here, we surveyed genome-scale shRNA and CRISPR screening data on hundreds of cancer cell lines and identified MAGO...

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Detalles Bibliográficos
Autores principales: Viswanathan, Srinivas R., Nogueira, Marina F., Buss, Colin G., Krill-Burger, John M., Wawer, Mathias J., Malolepsza, Edyta, Berger, Ashton C., Choi, Peter S., Shih, Juliann, Taylor, Alison M., Tanenbaum, Benjamin, Pedamallu, Chandra Sekhar, Cherniack, Andrew D., Tamayo, Pablo, Strathdee, Craig A., Lage, Kasper, Carr, Steven A., Schenone, Monica, Bhatia, Sangeeta N., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Meyerson, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143899/
https://www.ncbi.nlm.nih.gov/pubmed/29955178
http://dx.doi.org/10.1038/s41588-018-0155-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143899/
https://www.ncbi.nlm.nih.gov/pubmed/29955178
http://dx.doi.org/10.1038/s41588-018-0155-3

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