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Transient ischemia facilitates neuronal chloride accumulation and severity of seizures
OBJECTIVE: Preceding oxygen glucose deprivation (OGD) and ongoing seizures have both been reported to increase neuronal chloride concentration ([Cl(−)](i)), which may contribute to anticonvulsant failure by reversing the direction of chloride currents at inhibitory GABA(A) synapses. METHODS: The eff...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144438/ https://www.ncbi.nlm.nih.gov/pubmed/30250862 http://dx.doi.org/10.1002/acn3.617 |