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Transient ischemia facilitates neuronal chloride accumulation and severity of seizures

OBJECTIVE: Preceding oxygen glucose deprivation (OGD) and ongoing seizures have both been reported to increase neuronal chloride concentration ([Cl(−)](i)), which may contribute to anticonvulsant failure by reversing the direction of chloride currents at inhibitory GABA(A) synapses. METHODS: The eff...

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Detalles Bibliográficos
Autores principales:	Blauwblomme, Thomas, Dzhala, Volodymyr, Staley, Kevin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144438/ https://www.ncbi.nlm.nih.gov/pubmed/30250862 http://dx.doi.org/10.1002/acn3.617

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