ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells

The ATR kinase is crucial for genome maintenance, but the mechanisms by which ATR controls the DNA repair machinery are not fully understood. Here, we find that long-term chronic inhibition of ATR signaling severely impairs the ability of cells to utilize homologous recombination (HR)-mediated DNA r...

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Detalles Bibliográficos
Autores principales: Kim, Dongsung, Liu, Yi, Oberly, Susannah, Freire, Raimundo, Smolka, Marcus B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144784/
https://www.ncbi.nlm.nih.gov/pubmed/30010936
http://dx.doi.org/10.1093/nar/gky625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144784/
https://www.ncbi.nlm.nih.gov/pubmed/30010936
http://dx.doi.org/10.1093/nar/gky625

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