Cargando…

In vitro selection of an XNA aptamer capable of small-molecule recognition

Despite advances in XNA evolution, the binding capabilities of artificial genetic polymers are currently limited to protein targets. Here, we describe the expansion of in vitro evolution techniques to enable selection of threose nucleic acid (TNA) aptamers to ochratoxin A (OTA). This research establ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rangel, Alexandra E, Chen, Zhe, Ayele, Tewoderos M, Heemstra, Jennifer M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144807/ https://www.ncbi.nlm.nih.gov/pubmed/30085205 http://dx.doi.org/10.1093/nar/gky667

Ejemplares similares

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor
por: Eremeeva, Elena, et al.
Publicado: (2019)

Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis
por: Rietmeyer, Lauriane, et al.
Publicado: (2022)

In vitro selection of l-DNA aptamers that bind a structured d-RNA molecule
por: Dey, Sougata, et al.
Publicado: (2020)

Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase
por: Jackson, Lynnette N, et al.
Publicado: (2019)

Recognition of single-stranded nucleic acids by small-molecule splicing modulators
por: Tang, Zhichao, et al.
Publicado: (2021)

Circular L-RNA aptamer promotes target recognition and controls gene activity
por: Ji, Danyang, et al.
Publicado: (2021)

iSpinach: a fluorogenic RNA aptamer optimized for in vitro applications
por: Autour, Alexis, et al.
Publicado: (2016)

Periodic-shRNA molecules are capable of gene silencing, cytotoxicity and innate immune activation in cancer cells
por: Shopsowitz, Kevin E., et al.
Publicado: (2016)

Small-molecule affinity capture of DNA/RNA quadruplexes and their identification in vitro and in vivo through the G4RP protocol
por: Renard, Isaline, et al.
Publicado: (2019)

Triplex-forming properties and enzymatic incorporation of a base-modified nucleotide capable of duplex DNA recognition at neutral pH
por: Rusling, David A
Publicado: (2021)

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides
por: Baradaran-Heravi, Alireza, et al.
Publicado: (2016)

Inhibition of DNA replication by an anti-PCNA aptamer/PCNA complex
por: Kowalska, Ewa, et al.
Publicado: (2018)

Evolution of a highly functional circular DNA aptamer in serum
por: Mao, Yu, et al.
Publicado: (2020)

A DNA aptamer for binding and inhibition of DNA methyltransferase 1
por: Wang, Linlin, et al.
Publicado: (2019)

Genetically encoded RNA-based sensors with Pepper fluorogenic aptamer
por: Chen, Zhenyin, et al.
Publicado: (2023)

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
por: Yang, B., et al.
Publicado: (2015)

Tethered imidazole mediated duplex stabilization and its potential for aptamer stabilization
por: Verdonck, Lars, et al.
Publicado: (2018)

Salt-mediated two-site ligand binding by the cocaine-binding aptamer
por: Neves, Miguel A.D., et al.
Publicado: (2017)

Molecular affinity rulers: systematic evaluation of DNA aptamers for their applicabilities in ELISA
por: Kimoto, Michiko, et al.
Publicado: (2019)

G-quadruplex-forming aptamer enhances the peroxidase activity of myoglobin against luminol
por: Tsukakoshi, Kaori, et al.
Publicado: (2021)

Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif
por: Schofield, Peter, et al.
Publicado: (2023)

Selective targeting of parallel G-quadruplex structure using L-RNA aptamer
por: Ji, Danyang, et al.
Publicado: (2023)

Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung
por: Dang, Yan, et al.
Publicado: (2021)

Small synthetic molecule-stabilized RNA pseudoknot as an activator for –1 ribosomal frameshifting
por: Matsumoto, Saki, et al.
Publicado: (2018)

Specific suppression of D-RNA G-quadruplex–protein interaction with an L-RNA aptamer
por: Umar, Mubarak I, et al.
Publicado: (2020)

Structure–fluorescence activation relationships of a large Stokes shift fluorogenic RNA aptamer
por: Steinmetzger, Christian, et al.
Publicado: (2019)

A photochemically covalent lock stabilizes aptamer conformation and strengthens its performance for biomedicine
por: Zhou, Fang, et al.
Publicado: (2022)

A small-molecule fluorescence probe ANP77 for sensing RNA internal loop of C, U and A/CC motifs and their binding molecules
por: Das, Bimolendu, et al.
Publicado: (2021)

Mapping the affinity landscape of Thrombin-binding aptamers on 2΄F-ANA/DNA chimeric G-Quadruplex microarrays
por: Lietard, Jory, et al.
Publicado: (2017)

Dynamic topology of double-stranded telomeric DNA studied by single-molecule manipulation in vitro
por: Zhang, Xiaonong, et al.
Publicado: (2020)

Structure–activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides
por: Juliano, Rudolph L, et al.
Publicado: (2018)

Effect of small molecule eRF3 degraders on premature termination codon readthrough
por: Baradaran-Heravi, Alireza, et al.
Publicado: (2021)

Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen
por: Biondi, Elisa, et al.
Publicado: (2016)

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation
por: Yunn, Na-Oh, et al.
Publicado: (2015)

New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection
por: Zhang, Zijie, et al.
Publicado: (2017)

Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives
por: Virgilio, Antonella, et al.
Publicado: (2020)

A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer
por: Yunn, Na-Oh, et al.
Publicado: (2021)

Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe
por: Zhang, Suge, et al.
Publicado: (2018)

Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis
por: Tan, Yang, et al.
Publicado: (2022)

Small-molecule activators specific to adenine base editors through blocking the canonical TGF-β pathway
por: Yang, Yudong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u9ju8qb1sdk8ousu8en66v1mcd