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Absence of rapid selection for acyclovir or penciclovir resistance following suboptimal oral prodrug therapy of HSV-infected mice

BACKGROUND: Acyclovir (ACV) resistant herpes simplex virus (HSV) isolates can be readily selected in animal infection models receiving suboptimal ACV treatment, however no comparative studies of the emergence of resistance following suboptimal treatment with valacyclovir (VCV) or famciclovir (FCV),...

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Detalles Bibliográficos
Autores principales: Sarisky, Robert T, Bartus, H Ron, Dennis, Shelley A, Quail, Matthew R, Nguyen, Tammy T, Wittrock, Robert J, Halsey, Wendy S, Bacon, Teresa H, Leary, Jeffry J, Sutton, David
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC61449/
https://www.ncbi.nlm.nih.gov/pubmed/11749671
http://dx.doi.org/10.1186/1471-2334-1-24