Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis

Genome sequencing studies have revealed a number of cancer-associated mutations in the telomerebinding factor POT1. Here, we show that when combined with p53 deficiency, depletion of murine POT1a in common lymphoid progenitor cells fosters genetic instability, accelerates the onset, and increases th...

Descripción completa

Detalles Bibliográficos
Autores principales: Pinzaru, Alexandra M., Hom, Robert A., Beal, Angela, Phillips, Aaron F., Ni, Eric, Cardozo, Timothy, Nair, Nidhi, Choi, Jaehyuk, Wuttke, Deborah S., Sfeir, Agnel, Denchi, Eros Lazzerini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145145/
https://www.ncbi.nlm.nih.gov/pubmed/27239034
http://dx.doi.org/10.1016/j.celrep.2016.05.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145145/
https://www.ncbi.nlm.nih.gov/pubmed/27239034
http://dx.doi.org/10.1016/j.celrep.2016.05.008

Ejemplares similares