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Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis
Genome sequencing studies have revealed a number of cancer-associated mutations in the telomerebinding factor POT1. Here, we show that when combined with p53 deficiency, depletion of murine POT1a in common lymphoid progenitor cells fosters genetic instability, accelerates the onset, and increases th...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145145/ https://www.ncbi.nlm.nih.gov/pubmed/27239034 http://dx.doi.org/10.1016/j.celrep.2016.05.008 |