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Natural polymorphisms in the resistance associated sites of HCV-G1 NS5B domain and correlation with geographic origin of HCV isolates

BACKGROUND: We evaluated the frequency of naturally occurring resistance associated substitutions (RASs) and their characteristic of polymorphic or non-polymorphic amino acid change to direct acting antivirals (DAAs) in NS5b HCV subtypes 1a and 1b according to different geographic origin of isolates...

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Detalles Bibliográficos
Autores principales: Bagaglio, Sabrina, Uberti-Foppa, Caterina, Olgiati, Alessandro, Messina, Emanuela, Hasson, Hamid, Ferri, Camilla, Morsica, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145338/
https://www.ncbi.nlm.nih.gov/pubmed/30227876
http://dx.doi.org/10.1186/s12985-018-1054-z