An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties

Cellular function depends on the maintenance of protein homeostasis (proteostasis) by regulated protein degradation. Chronic dysregulation of proteostasis is associated with neurodegenerative and age-related diseases, and drugs targeting components of the protein degradation apparatus are increasing...

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Detalles Bibliográficos
Autores principales: Loaiza, Sandra, Ferreira, Silvia A., Chinn, Tamara M., Kirby, Alex, Tsolaki, Elena, Dondi, Camilla, Parzych, Katarzyna, Strange, Adam P., Bozec, Laurent, Bertazzo, Sergio, Hedegaard, Martin A.B., Gentleman, Eileen, Auner, Holger W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145445/
https://www.ncbi.nlm.nih.gov/pubmed/30153561
http://dx.doi.org/10.1016/j.biomaterials.2018.08.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145445/
https://www.ncbi.nlm.nih.gov/pubmed/30153561
http://dx.doi.org/10.1016/j.biomaterials.2018.08.041

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