Nuclear Arp2/3 drives DNA break clustering for homology-directed repair

DNA double-strand breaks (DSBs) repaired by non-homologous end joining (NHEJ) display limited DNA end processing and chromosomal mobility. In contrast, DSBs undergoing homology-directed repair (HDR) exhibit extensive processing and enhanced motion. The molecular basis for this movement is unknown. U...

Descripción completa

Detalles Bibliográficos
Autores principales: Schrank, Benjamin R., Aparicio, Tomas, Li, Yinyin, Chang, Wakam, Chait, Brian T., Gundersen, Gregg G., Gottesman, Max E., Gautier, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145447/
https://www.ncbi.nlm.nih.gov/pubmed/29925947
http://dx.doi.org/10.1038/s41586-018-0237-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145447/
https://www.ncbi.nlm.nih.gov/pubmed/29925947
http://dx.doi.org/10.1038/s41586-018-0237-5

Ejemplares similares