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Nuclear Arp2/3 drives DNA break clustering for homology-directed repair

DNA double-strand breaks (DSBs) repaired by non-homologous end joining (NHEJ) display limited DNA end processing and chromosomal mobility. In contrast, DSBs undergoing homology-directed repair (HDR) exhibit extensive processing and enhanced motion. The molecular basis for this movement is unknown. U...

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Detalles Bibliográficos
Autores principales:	Schrank, Benjamin R., Aparicio, Tomas, Li, Yinyin, Chang, Wakam, Chait, Brian T., Gundersen, Gregg G., Gottesman, Max E., Gautier, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145447/ https://www.ncbi.nlm.nih.gov/pubmed/29925947 http://dx.doi.org/10.1038/s41586-018-0237-5

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