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Impact of repeated anesthesia with ketamine and xylazine on the well-being of C57BL/6JRj mice
Within the scope of the 3Rs of Russel and Burch, the number of laboratory animals can be reduced by repeated use of an animal. This strategy only becomes relevant, if the total amount of pain, distress or harm the individual animal experiences does not exceed the severity of a single manipulation. F...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145541/ https://www.ncbi.nlm.nih.gov/pubmed/30231081 http://dx.doi.org/10.1371/journal.pone.0203559 |