mTORC1/2 inhibition re-sensitizes platinum-resistant ovarian cancer by disrupting selective translation of DNA damage and survival mRNAs

Platinum resistance is a major cause of treatment failure and mortality in epithelial ovarian cancer. mTORC1/2 inhibitors, which impair mRNA translation, can re-sensitize resistant ovarian cancer cells to platinum chemotherapy but the mechanism remains poorly described. Using platinum-resistant OVCA...

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Detalles Bibliográficos
Autores principales: David-West, Gizelka, Ernlund, Amanda, Gadi, Abhilash, Schneider, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145695/
https://www.ncbi.nlm.nih.gov/pubmed/30237852
http://dx.doi.org/10.18632/oncotarget.25869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145695/
https://www.ncbi.nlm.nih.gov/pubmed/30237852
http://dx.doi.org/10.18632/oncotarget.25869

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