A role for APP in Wnt signalling links synapse loss with β-amyloid production

In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability, while non-canonical (Wnt-PCP) signalling favours synaps...

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Detalles Bibliográficos
Autores principales: Elliott, Christina, Rojo, Ana I., Ribe, Elena, Broadstock, Martin, Xia, Weiming, Morin, Peter, Semenov, Mikhail, Baillie, George, Cuadrado, Antonio, Al-Shawi, Raya, Ballard, Clive G., Simons, Paul, Killick, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145937/
https://www.ncbi.nlm.nih.gov/pubmed/30232325
http://dx.doi.org/10.1038/s41398-018-0231-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145937/
https://www.ncbi.nlm.nih.gov/pubmed/30232325
http://dx.doi.org/10.1038/s41398-018-0231-6

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