Cargando…

A role for APP in Wnt signalling links synapse loss with β-amyloid production

In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability, while non-canonical (Wnt-PCP) signalling favours synaps...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elliott, Christina, Rojo, Ana I., Ribe, Elena, Broadstock, Martin, Xia, Weiming, Morin, Peter, Semenov, Mikhail, Baillie, George, Cuadrado, Antonio, Al-Shawi, Raya, Ballard, Clive G., Simons, Paul, Killick, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145937/ https://www.ncbi.nlm.nih.gov/pubmed/30232325 http://dx.doi.org/10.1038/s41398-018-0231-6

Ejemplares similares

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil
por: Sellers, Katherine J., et al.
Publicado: (2018)

Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer’s Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil
por: Killick, Richard, et al.
Publicado: (2023)

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway
por: Killick, R, et al.
Publicado: (2014)

A genetically immortalized human stem cell line: a promising new tool for Alzheimer's disease therapy
por: Puangmalai, Nicha, et al.
Publicado: (2015)

Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo
por: Al-Shawi, Raya, et al.
Publicado: (2016)

Enhanced neuronal degradation of amyloid-β oligomers allows synapse regeneration
por: Bate, Clive
Publicado: (2015)

Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-β
por: Bate, Clive
Publicado: (2017)

α-synuclein induced synapse damage is enhanced by amyloid-β(1-42)
por: Bate, Clive, et al.
Publicado: (2010)

Ginkgolides protect against amyloid-β(1–42)-mediated synapse damage in vitro
por: Bate, Clive, et al.
Publicado: (2008)

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology
por: Rojo, Ana I., et al.
Publicado: (2017)

Transcription-based drug repurposing for COVID-19
por: Killick, Richard, et al.
Publicado: (2020)

Heterogeneous Association of Alzheimer’s Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses
por: Willén, Katarina, et al.
Publicado: (2017)

Amyloids: Regulators of Metal Homeostasis in the Synapse
por: Kawahara, Masahiro, et al.
Publicado: (2020)

In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease
por: Kim, Eugene, et al.
Publicado: (2021)

Wnt signalling in the development of axon, dendrites and synapses
por: He, Chun-Wei, et al.
Publicado: (2018)

cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-β-Induced Synapse Damage
por: Bate, Clive, et al.
Publicado: (2015)

Amyloid persistence in decellularized liver: biochemical and histopathological characterization
por: Mazza, Giuseppe, et al.
Publicado: (2016)

Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A(2) and Synapse Damage
por: West, Ewan, et al.
Publicado: (2015)

APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins
por: Guénette, Suzanne, et al.
Publicado: (2017)

PSD-95 protects synapses from β-amyloid
por: Dore, Kim, et al.
Publicado: (2021)

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
por: Killick, Richard, et al.
Publicado: (2009)

Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes
por: Lee, Sang H., et al.
Publicado: (2018)

Commentary: APP as a Mediator of the Synapse Pathology in Alzheimer's Disease
por: Schreurs, An, et al.
Publicado: (2018)

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus
por: Marzo, Aude, et al.
Publicado: (2016)

Striatal Synapse Degeneration and Dysfunction Are Reversed by Reactivation of Wnt Signaling
por: Galli, Soledad, et al.
Publicado: (2021)

Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation
por: Teo, Samuel, et al.
Publicado: (2021)

Amyloid, APP, and Electrical Activity of the Brain
por: Hefter, Dimitri, et al.
Publicado: (2019)

Wnt-5a induces the conversion of silent to functional synapses in the hippocampus
por: Álvarez-Ferradas, Carla, et al.
Publicado: (2022)

Vascular amyloid accumulation alters the gabaergic synapse and induces hyperactivity in a model of cerebral amyloid angiopathy
por: Cisternas, Pablo, et al.
Publicado: (2020)

Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates
por: Mulugeta, Ezra, et al.
Publicado: (2011)

Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses
por: Romani, Armando, et al.
Publicado: (2013)

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
por: Zhang, Xiaojie, et al.
Publicado: (2013)

Amyloid Precursor Protein (APP) and GABAergic Neurotransmission
por: Tang, Bor Luen
Publicado: (2019)

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons
por: Robbins, Jacqueline P., et al.
Publicado: (2018)

Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis
por: Slamova, Ivana, et al.
Publicado: (2021)

Neurogenesis, Neurodegeneration, Interneuron Vulnerability, and Amyloid-β in the Olfactory Bulb of APP/PS1 Mouse Model of Alzheimer's Disease
por: De la Rosa-Prieto, Carlos, et al.
Publicado: (2016)

Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells
por: Ristori, Emma, et al.
Publicado: (2020)

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production
por: Nowakowska-Gołacka, Jowita, et al.
Publicado: (2021)

β-Amyloid precursor protein (APP) and the human diseases
por: Nguyen, Khue Vu
Publicado: (2019)

Dissecting Molecular Differences between Wnt Coreceptors LRP5 and LRP6
por: MacDonald, Bryan T., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_fbg3boqjk3raf3hqp58mlc2ohl