Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300

Ageing is the primary risk factor for osteoarthritis (OA). A decline in the ageing-associated process of autophagy is suggested as a potential contributor to OA development. Polyamines such as spermidine decrease during ageing, contributing to impaired autophagy and reduced cellular function. Howeve...

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Detalles Bibliográficos
Autores principales: Sacitharan, Pradeep K., Lwin, Seint, Gharios, George Bou, Edwards, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145946/
https://www.ncbi.nlm.nih.gov/pubmed/30232322
http://dx.doi.org/10.1038/s12276-018-0149-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145946/
https://www.ncbi.nlm.nih.gov/pubmed/30232322
http://dx.doi.org/10.1038/s12276-018-0149-3

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