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Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?

At least 10% of the elderly population above the age of 70 carry a condition termed clonal hematopoiesis indeterminate potential (CHIP) due to oligoclonal expansion of mutated hematopoietic stem cells. Although CHIP is known to predispose patients to a higher risk of malignant blood disorders, the r...

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Detalles Bibliográficos
Autores principales: Li, Fei, Wu, Xiaojing, Zhou, Qi, Zhu, Dennis Weixi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146228/
https://www.ncbi.nlm.nih.gov/pubmed/30258936
http://dx.doi.org/10.1016/j.gendis.2018.04.001
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author Li, Fei
Wu, Xiaojing
Zhou, Qi
Zhu, Dennis Weixi
author_facet Li, Fei
Wu, Xiaojing
Zhou, Qi
Zhu, Dennis Weixi
author_sort Li, Fei
collection PubMed
description At least 10% of the elderly population above the age of 70 carry a condition termed clonal hematopoiesis indeterminate potential (CHIP) due to oligoclonal expansion of mutated hematopoietic stem cells. Although CHIP is known to predispose patients to a higher risk of malignant blood disorders, the recent revelation of its association with higher morbidity and mortality of atherosclerotic cardiovascular disease and ischemic stroke is rather surprising. Two independent research groups published studies indicating that Tet2 mutated monocytes from mice modeling CHIP had a causal role in accelerating the growth of atherosclerotic lesions due to their pro-inflammation activities. This important discovery points to CHIP as a risk factor and raises the prospect of novel treatment to minimize the adverse cardio/cerebro-vascular events.
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spelling pubmed-61462282018-09-26 Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases? Li, Fei Wu, Xiaojing Zhou, Qi Zhu, Dennis Weixi Genes Dis Article At least 10% of the elderly population above the age of 70 carry a condition termed clonal hematopoiesis indeterminate potential (CHIP) due to oligoclonal expansion of mutated hematopoietic stem cells. Although CHIP is known to predispose patients to a higher risk of malignant blood disorders, the recent revelation of its association with higher morbidity and mortality of atherosclerotic cardiovascular disease and ischemic stroke is rather surprising. Two independent research groups published studies indicating that Tet2 mutated monocytes from mice modeling CHIP had a causal role in accelerating the growth of atherosclerotic lesions due to their pro-inflammation activities. This important discovery points to CHIP as a risk factor and raises the prospect of novel treatment to minimize the adverse cardio/cerebro-vascular events. Chongqing Medical University 2018-04-12 /pmc/articles/PMC6146228/ /pubmed/30258936 http://dx.doi.org/10.1016/j.gendis.2018.04.001 Text en © 2018 Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Li, Fei
Wu, Xiaojing
Zhou, Qi
Zhu, Dennis Weixi
Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?
title Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?
title_full Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?
title_fullStr Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?
title_full_unstemmed Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?
title_short Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?
title_sort clonal hematopoiesis of indeterminate potential (chip): a potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146228/
https://www.ncbi.nlm.nih.gov/pubmed/30258936
http://dx.doi.org/10.1016/j.gendis.2018.04.001
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