Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition

Protein degradation is essential to compensate for the damaging effects of proteotoxic stress. To ensure protein and redox homeostasis in response to proteasome inhibition, the cleavage and nuclear translocation of the endoplasmic reticulum (ER)-bound transcription factor TCF11/Nrf1 (NFE2L1) is cruc...

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Detalles Bibliográficos
Autores principales: Nowak, Karolin, Taubert, Ramona M., Haberecht, Stefanie, Venz, Simone, Krüger, Elke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146291/
https://www.ncbi.nlm.nih.gov/pubmed/30177525
http://dx.doi.org/10.1042/BSR20180393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146291/
https://www.ncbi.nlm.nih.gov/pubmed/30177525
http://dx.doi.org/10.1042/BSR20180393

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