Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension

Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca(2+)-ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a resulted in homogenous distribution of vectors, lowe...

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Detalles Bibliográficos
Autores principales: Watanabe, Shin, Ishikawa, Kiyotake, Plataki, Maria, Bikou, Olympia, Kohlbrenner, Erik, Aguero, Jaume, Hadri, Lahouaria, Zarragoikoetxea, Iratxe, Fish, Kenneth, Leopold, Jane A., Hajjar, Roger J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146327/
https://www.ncbi.nlm.nih.gov/pubmed/30129881
http://dx.doi.org/10.1177/2045894018799738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146327/
https://www.ncbi.nlm.nih.gov/pubmed/30129881
http://dx.doi.org/10.1177/2045894018799738

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