Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension

Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca(2+)-ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a resulted in homogenous distribution of vectors, lowe...

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Autores principales: Watanabe, Shin, Ishikawa, Kiyotake, Plataki, Maria, Bikou, Olympia, Kohlbrenner, Erik, Aguero, Jaume, Hadri, Lahouaria, Zarragoikoetxea, Iratxe, Fish, Kenneth, Leopold, Jane A., Hajjar, Roger J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146327/
https://www.ncbi.nlm.nih.gov/pubmed/30129881
http://dx.doi.org/10.1177/2045894018799738
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author Watanabe, Shin
Ishikawa, Kiyotake
Plataki, Maria
Bikou, Olympia
Kohlbrenner, Erik
Aguero, Jaume
Hadri, Lahouaria
Zarragoikoetxea, Iratxe
Fish, Kenneth
Leopold, Jane A.
Hajjar, Roger J.
author_facet Watanabe, Shin
Ishikawa, Kiyotake
Plataki, Maria
Bikou, Olympia
Kohlbrenner, Erik
Aguero, Jaume
Hadri, Lahouaria
Zarragoikoetxea, Iratxe
Fish, Kenneth
Leopold, Jane A.
Hajjar, Roger J.
author_sort Watanabe, Shin
collection PubMed
description Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca(2+)-ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a resulted in homogenous distribution of vectors, lower pulmonary vascular resistance, and a trend towards better long-term survival compared to control animals.
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spelling pubmed-61463272018-09-21 Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension Watanabe, Shin Ishikawa, Kiyotake Plataki, Maria Bikou, Olympia Kohlbrenner, Erik Aguero, Jaume Hadri, Lahouaria Zarragoikoetxea, Iratxe Fish, Kenneth Leopold, Jane A. Hajjar, Roger J. Pulm Circ Research Letter Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca(2+)-ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a resulted in homogenous distribution of vectors, lower pulmonary vascular resistance, and a trend towards better long-term survival compared to control animals. SAGE Publications 2018-08-21 /pmc/articles/PMC6146327/ /pubmed/30129881 http://dx.doi.org/10.1177/2045894018799738 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Letter
Watanabe, Shin
Ishikawa, Kiyotake
Plataki, Maria
Bikou, Olympia
Kohlbrenner, Erik
Aguero, Jaume
Hadri, Lahouaria
Zarragoikoetxea, Iratxe
Fish, Kenneth
Leopold, Jane A.
Hajjar, Roger J.
Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension
title Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension
title_full Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension
title_fullStr Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension
title_full_unstemmed Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension
title_short Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension
title_sort safety and long-term efficacy of aav1.serca2a using nebulizer delivery in a pig model of pulmonary hypertension
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146327/
https://www.ncbi.nlm.nih.gov/pubmed/30129881
http://dx.doi.org/10.1177/2045894018799738
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