Cargando…
All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo
BACKGROUND: Clustered, regularly interspaced, short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) have recently opened a new avenue for gene therapy. Cas9 nuclease guided by a single-guide RNA (sgRNA) has been extensively used for genome editing. Currently, three Cas9 orthologs h...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146650/ https://www.ncbi.nlm.nih.gov/pubmed/30231914 http://dx.doi.org/10.1186/s13059-018-1515-0 |